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Effects of CYP3A5*3 genetic polymorphisms on the pharmacokinetics of perampanel in Chinese pediatric patients with epilepsy.

Pharmacogenetics and genomics - 1 Aug 2024

Zhao Ting, Feng Ji-Rong, Zhang Hui-Lan, Yu Jing, Feng Jie, Sun Ke-Fang, Yu Lu-Hai, Sun Yan, Li Hong-Jian

Abstract excerpt

PURPOSE: This study was the first to evaluate the effect of CYP3A5*3 gene polymorphisms on plasma concentration of perampanel (PER) in Chinese pediatric patients with epilepsy. METHODS: We enrolled 98 patients for this investigation. Plasma PER concentrations were measured using liquid chromatography-tandem mass spectrometry. Leftover samples from standard therapeutic drug monitoring were allocated for genotyping...

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PMID: 38728170
DOI: 10.1097/FPC.0000000000000535

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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