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Article

Pharmacogenetic Variants and Plasma Concentrations of Antiseizure Drugs: A Systematic Review and Meta-Analysis.

JAMA network open - 1 Aug 2024

Milosavljevic Filip, Manojlovic Marina, Matkovic Lena, Molden Espen, Ingelman-Sundberg Magnus, Leucht Stefan, Jukic Marin M

Abstract excerpt

Importance: Precise estimation of a patient's drug metabolism capacity is important for antiseizure dose personalization. Objective: To quantify the differences in plasma concentrations for antiseizure drugs associated with variants of genes encoding drug metabolizing enzymes. Data Sources: PubMed, Clinicaltrialsregister.eu, ClinicalTrials.gov, International Clinical Trials Registry Platform, and CENTRAL...

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Identifiers

PMID: 39115847
DOI: 10.1001/jamanetworkopen.2024.25593
PMCID: PMC11310823

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