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Article

Effects of CYP3A4 genetic polymorphisms on the pharmacokinetics and efficacy of perampanel in Chinese pediatric patients with epilepsy.

Seizure - 1 Aug 2024

Zhao Ting, Li Hong-Jian, Zhang Hui-Lan, Feng Ji-Rong, Yu Jing, Sun Ke-Fang, Feng Jie, Sun Yan, Yu Lu-Hai

Abstract excerpt

OBJECTIVE: This study was the first to evaluate the effect of CYP3A4 gene polymorphisms on the plasma concentration and effectiveness of perampanel (PER) in Chinese pediatric patients with epilepsy. METHODS: We enrolled 102 patients for this investigation. The steady-state concentration was determined after patients maintained a consistent PER dosing regimen for at least 21 days. Plasma PER concentrations were...

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PMID: 38996572
DOI: 10.1016/j.seizure.2024.07.006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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