Article
Donor KIR2DL1 Allelic Polymorphism Influences Posthematopoietic Progenitor Cell Transplantation Outcomes in the T Cell Depleted and Reduced Intensity Conditioning Setting.
Transplantation and cellular therapy - 1 May 2024
Wright Paul A, van de Pasch Loes A L, Dignan Fiona L, Kichula Katherine M, Pollock Nicholas R, Norman Paul J, Marchan Earl, Hill Lesley, Vandelbosch Sanne, Fullwood Catherine, Sheldon Stephen, Hampson Lynne, Tholouli Eleni, Poulton Kay V
Abstract excerpt
The majority of established KIR clinical assessment algorithms used for donor selection for hematopoietic progenitor cell transplantation (HPCT) evaluate gene content (presence/absence) of the KIR gene complex. In comparison, relatively little is known about the impact of KIR allelic polymorphism. By analyzing donors of T cell depleted (TcD) reduced intensity conditioning (RIC) HPCT, this study investigated the...
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