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Article

Transactivation of Met signaling by oncogenic Gnaq drives the evolution of melanoma in Hgf-Cdk4 mice.

Cancer gene therapy - 1 Jun 2024

Mengoni Miriam, Braun Andreas Dominik, Seedarala Sahithi, Bonifatius Susanne, Kostenis Evi, Schanze Denny, Zenker Martin, Tüting Thomas, Gaffal Evelyn

Abstract excerpt

Recent pan-cancer genomic analyses have identified numerous oncogenic driver mutations that occur in a cell-type and tissue-specific distribution. For example, oncogenic mutations in Braf and Nras genes arise predominantly in melanocytic neoplasms of the epidermis, while oncogenic mutations in Gnaq/11 genes arise mostly in melanocytic lesions of the dermis or the uvea. The mechanisms promoting cell-type and...

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Share to Cyclin-Dependent Kinase 4
Share to GTP-Binding Protein alpha Subunits, Gq-G11

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hepatocyte Growth Factor

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Source

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Identifiers

PMID: 38360887
DOI: 10.1038/s41417-024-00744-0
PMCID: PMC11192630

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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