Article
Oncogenic mutations in GNAQ occur early in uveal melanoma.
Investigative ophthalmology & visual science - 1 Dec 2008
Onken Michael D, Worley Lori A, Long Meghan D, Duan Shenghui, Council M Laurin, Bowcock Anne M, Harbour J William
Abstract excerpt
PURPOSE: Early/initiating oncogenic mutations have been identified for many cancers, but such mutations remain unidentified in uveal melanoma (UM). An extensive search for such mutations was undertaken, focusing on the RAF/MEK/ERK pathway, which is often the target of initiating mutations in other types of cancer. METHODS: DNA samples from primary UMs were analyzed for mutations in 24 potential oncogenes that...
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