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Article

Comprehensive epigenetic landscape of rheumatoid arthritis fibroblast-like synoviocytes

9 May 2018

Abstract excerpt

Epigenetics contributes to the pathogenesis of immune-mediated diseases like rheumatoid arthritis (RA). Here we show the first comprehensive epigenomic characterization of RA fibroblast-like synoviocytes (FLS), including histone modifications (H3K27ac, H3K4me1, H3K4me3, H3K36me3, H3K27me3, and H3K9me3), open chromatin, RNA expression and whole-genome DNA methylation. To address complex multidimensional...

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PMID: 29765031
DOI: 10.1038/s41467-018-04310-9

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