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Phenotypic and genome-wide studies on dicarbonyls: major associations to glomerular filtration rate and gamma-glutamyltransferase activity.

EBioMedicine - 1 Mar 2024

Harrer Philip, Inderhees Julica, Zhao Chen, Schormair Barbara, Tilch Erik, Gieger Christian, Peters Annette, Jöhren Olaf, Fleming Thomas, Nawroth Peter P, Berger Klaus, Hermesdorf Marco, Winkelmann Juliane, Schwaninger Markus, Oexle Konrad

Abstract excerpt

BACKGROUND: The dicarbonyl compounds methylglyoxal (MG), glyoxal (GO) and 3-deoxyglucosone (3-DG) have been linked to various diseases. However, disease-independent phenotypic and genotypic association studies with phenome-wide and genome-wide reach, respectively, have not been provided. METHODS: MG, GO and 3-DG were measured by LC-MS in 1304 serum samples of two populations (KORA, n = 482; BiDirect, n = 822) and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38354534
DOI: 10.1016/j.ebiom.2024.105007
PMCID: PMC10875252

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