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Article

Plasma Glutaminyl-Peptide Cyclotransferase Mediates Glucosamine-Metabolism-Driven Protection Against Hypertension: A Mendelian Randomization Study.

International journal of molecular sciences - 11 Nov 2024

Ge Fei, Sun Yu, Han Cong-Cong, Wei Zi-Liang, Guan Xin, Guo Si-Wan, Quan Shui, Zhou Jia-Guo, Pang Rui-Ping

Abstract excerpt

Hypertension is one of the major risk factors for morbidity and mortality worldwide. In this study, Mendelian randomization was utilized to investigate how dietary supplement intake can impact hypertension based on circulating plasma metabolite genome-wide association study (GWAS) datasets, protein quantitative trait loci (pQTLs) of plasma proteins, and multiple public summary-level GWAS data. Pathway enrichment...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39596173
DOI: 10.3390/ijms252212106
PMCID: PMC11593689

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