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Article

Associations of dicarbonyl stress with complement activation: the CODAM study.

Diabetologia - 1 May 2020

Xin Ying, Hertle Elisabeth, van der Kallen Carla J H, Schalkwijk Casper G, Stehouwer Coen D A, van Greevenbroek Marleen M J

Abstract excerpt

AIMS/HYPOTHESIS: Reactive α-dicarbonyl compounds are major precursors of AGEs and may lead to glycation of circulating and/or cell-associated complement regulators. Glycation of complement regulatory proteins can influence their capacity to inhibit complement activation. We investigated, in a human cohort, whether greater dicarbonyl stress was associated with more complement activation. METHODS: Circulating...

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Identifiers

PMID: 31993713
DOI: 10.1007/s00125-020-05098-4
PMCID: PMC7145776

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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