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Article

Relapsed classic E-cadherin (CDH1)-mutated invasive lobular breast cancer shows a high frequency of HER2 (ERBB2) gene mutations.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 May 2013

Ross Jeffrey S, Wang Kai, Sheehan Christine E, Boguniewicz Ann B, Otto Geoff, Downing Sean R, Sun James, He Jie, Curran John A, Ali Siraj, Yelensky Roman, Lipson Doron, Palmer Gary, Miller Vincent A, Stephens Philip J

Abstract excerpt

PURPOSE: We queried whether comprehensive genomic profiling using a next-generation sequencing-based assay could identify novel and unanticipated targets of therapy for patients with relapsed invasive lobular carcinoma (ILC). EXPERIMENTAL DESIGN: DNA sequencing (Illumina HiSeq 2000) was conducted...

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Source

Identifiers

PMID: 23575477
DOI: 10.1158/1078-0432.CCR-13-0295

Genes

ERBB2
CDH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23575477-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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