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Article

Accounting for isoform expression increases power to identify genetic regulation of gene expression.

PLoS computational biology - 1 Feb 2024

LaPierre Nathan, Pimentel Harold

Abstract excerpt

A core problem in genetics is molecular quantitative trait locus (QTL) mapping, in which genetic variants associated with changes in the molecular phenotypes are identified. One of the most-studied molecular QTL mapping problems is expression QTL (eQTL) mapping, in which the molecular phenotype is gene expression. It is common in eQTL mapping to compute gene expression by aggregating the expression levels of...

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Identifiers

PMID: 38346082
DOI: 10.1371/journal.pcbi.1011857
PMCID: PMC10890775

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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