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Article

Determinants of early change in serum creatinine after initiation of dolutegravir-based antiretroviral therapy in South Africa.

British journal of clinical pharmacology - 1 May 2024

Mpofu Rephaim, Kawuma Aida N, Wasmann Roeland E, Akpomiemie Godspower, Chandiwana Nomathemba, Sokhela Simiso Mandisa, Moorhouse Michelle, Venter Willem Daniel Francois, Denti Paolo, Wiesner Lubbe, Post Frank A, Haas David W, Maartens Gary, Sinxadi Phumla

Abstract excerpt

AIMS: Dolutegravir increases serum creatinine by inhibiting its renal tubular secretion and elimination. We investigated determinants of early changes in serum creatinine in a southern African cohort starting first-line dolutegravir-based antiretroviral therapy (ART). METHODS: We conducted a secondary analysis of data from participants in a randomized controlled trial of dolutegravir, emtricitabine and tenofovir...

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Identifiers

PMID: 38332460
DOI: 10.1111/bcp.16009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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