Article
Genetic and non-genetic factors influencing efavirenz population pharmacokinetics among human immunodeficiency virus-1-infected children in Ethiopia.
CPT: pharmacometrics & systems pharmacology - 1 Jun 2023
Chala Adugna, Kitabi Eliford Ngaimisi, Ahmed Jemal Hussien, Tadesse Birkneh Tilahun, Chaka Tolossa Eticha, Makonnen Eyasu, Aklillu Eleni
Abstract excerpt
Despite the potential for efavirenz (EFV) to be an effective alternative antiretroviral agent, its sources of wide inter- and intra-individual pharmacokinetic (PK) variability are not well-characterized in children. We investigated the effects of genetic and non-genetic factors, including demographic, treatment duration, baseline clinical, and biochemical characteristics, on the PKs of EFV through population-PK...
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