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Article

Impact of Genetic Variants in ABCG2 , NR1I2 , and UGT1A1 on the Pharmacokinetics of Dolutegravir in Children.

Journal of acquired immune deficiency syndromes (1999) - 1 Mar 2024

Spector Stephen A, Brummel Sean S, Chang Audrey, Wiznia Andrew, Ruel Theodore D, Acosta Edward P

Abstract excerpt

BACKGROUND: Dolutegravir plasma concentrations and pharmacokinetic (PK) parameters in children display considerable variability. Here, the impact of genetic variants in ABCG2 421C>A (rs2231142), NR1I2 63396 C>T (rs2472677), and UGT1A1 (rs5839491) on dolutegravir PK was examined. METHODS: Children defined by age and administered dolutegravir formulation had AUC 24 at steady state, C max and C 24h determined....

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Identifiers

PMID: 38180896
DOI: 10.1097/QAI.0000000000003358
PMCID: PMC10922521

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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