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UGT1A1 regulatory variant with potential effect on efficacy of HIV and cancer drugs commonly prescribed in South Africa.

Pharmacogenomics - 1 Oct 2021

Mathew Jenny Mary, Mpangase Phelelani Thokozani, Sengupta Dhriti, Kwenda Stanford, Mavri-Damelin Demetra, Ramsay Michèle

Abstract excerpt

Aim: Despite the high disease burden of human immunodeficiency virus (HIV) infection and colorectal cancer (CRC) in South Africa (SA), treatment-relevant pharmacogenetic variants are understudied. Materials & methods: Using publicly available genotype and gene expression data, a bioinformatic pipeline was developed to identify liver expression quantitative trait loci (eQTLs). Results: A novel cis-eQTL,...

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PMID: 34528449
DOI: 10.2217/pgs-2021-0062

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