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Immune-metabolic crosstalk in HNSCC: mechanisms and therapeutic opportunities

15 May 2025

Abstract excerpt

Head and neck squamous cell carcinoma (HNSCC) is a prevalent malignancy, characterized by metabolic reprogramming. This reprogramming creates an acidic and hypoxic environment within tumor cells to adapt to metabolic changes. Experimental data indicate that in HNSCC, the metabolic reprogramming of tumor cells regulates immune cells via metabolites or signaling pathways, thereby promoting cancer progression or...

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PMID: 40444100
DOI: 10.3389/fonc.2025.1553284

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