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Article

Contributions of mouse genetic strain background to age-related phenotypes in physically active HET3 mice.

Neurobiology of aging - 1 Apr 2024

Willows Jake W, Alshahal Zahra, Story Naeemah M, Alves Michele J, Vidal Pablo, Harris Hallie, Rodrigo Rochelle, Stanford Kristin I, Peng Juan, Reifsnyder Peter C, Harrison David E, David Arnold W, Townsend Kristy L

Abstract excerpt

We assessed aging hallmarks in skin, muscle, and adipose in the genetically diverse HET3 mouse, and generated a broad dataset comparing these to individual animal diagnostic SNPs from the 4 founding inbred strains of the HET3 line. For middle- and old-aged HET3 mice, we provided running wheel exercise to ensure our observations were not purely representative of sedentary animals, but age-related phenotypes were...

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PMID: 38325031
DOI: 10.1016/j.neurobiolaging.2024.01.010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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