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Article

Heritability of fat distributions in male mice from the founder strains of the Diversity Outbred mouse population.

G3 (Bethesda, Md.) - 7 May 2021

Keenan Brendan T, Webster Jeanette C, Wiemken Andrew S, Lavi-Romer Nir, Nguyen Teresa, Svenson Karen L, Galante Raymond J, Churchill Gary A, Pickup Stephen, Pack Allan I, Schwab Richard J

Abstract excerpt

Specific fat distributions are risk factors for complex diseases, including coronary heart disease and obstructive sleep apnea. To demonstrate the utility of high-diversity mouse models for elucidating genetic associations, we describe the phenotyping and heritability of fat distributions within the five classical inbred and three wild-derived founder mouse strains of the Collaborative Cross and Diversity Outbred...

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Identifiers

PMID: 33720343
DOI: 10.1093/g3journal/jkab079
PMCID: PMC8104956

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