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Article

Substrains matter in phenotyping of C57BL/6 mice.

Experimental animals - 13 May 2021

Mekada Kazuyuki, Yoshiki Atsushi

Abstract excerpt

The inbred mouse strain C57BL/6 has been widely used as a background strain for spontaneous and induced mutations. Developed in the 1930s, the C57BL/6 strain diverged into two major groups in the 1950s, namely, C57BL/6J and C57BL/6N, and more than 20 substrains have been established from them worldwide. We previously reported genetic differences among C57BL/6 substrains in 2009 and 2015. Since then, dozens of...

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Identifiers

PMID: 33441510
DOI: 10.1538/expanim.20-0158
PMCID: PMC8150240

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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