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Article

Internal Disequilibria and Phenotypic Diversification during Replication of Hepatitis C Virus in a Noncoevolving Cellular Environment.

Journal of virology - 15 May 2017

Moreno Elena, Gallego Isabel, Gregori Josep, Lucía-Sanz Adriana, Soria María Eugenia, Castro Victoria, Beach Nathan M, Manrubia Susanna, Quer Josep, Esteban Juan Ignacio, Rice Charles M, Gómez Jordi, Gastaminza Pablo, Domingo Esteban, Perales Celia

Abstract excerpt

Viral quasispecies evolution upon long-term virus replication in a noncoevolving cellular environment raises relevant general issues, such as the attainment of population equilibrium, compliance with the molecular-clock hypothesis, or stability of the phenotypic profile. Here, we evaluate the adaptation, mutant spectrum dynamics, and phenotypic diversification of hepatitis C virus (HCV) in the course of 200...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28275194
DOI: 10.1128/JVI.02505-16
PMCID: PMC5411618

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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