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Article

Oncogenic Roles of GOLPH3 in the Physiopathology of Cancer

31 Jan 2020

Abstract excerpt

Golgi phosphoprotein 3 (GOLPH3), a Phosphatidylinositol 4-Phosphate [PI(4)P] effector at the Golgi, is required for Golgi ribbon structure maintenance, vesicle trafficking and Golgi glycosylation. GOLPH3 has been validated as an oncoprotein through combining integrative genomics with clinopathological and functional analyses. It is frequently amplified in several solid tumor types including melanoma, lung cancer,...

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PMID: 32023813
DOI: 10.3390/ijms21030933

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