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Article

EZH2 Palmitoylation Mediated by ZDHHC5 in p53-Mutant Glioma Drives Malignant Development and Progression.

Cancer research - 15 Sept 2017

Chen Xueran, Ma Huihui, Wang Zhen, Zhang Shangrong, Yang Haoran, Fang Zhiyou

Abstract excerpt

Gliomas with mutant p53 occurring in 30% of glioma patients exhibit therapeutic resistance and poor outcomes. In this study, we identify a novel mechanism through which mutant p53 drives cancer cell survival and malignant growth. We documented overexpression of the zinc finger protein ZDHHC5 in glioma compared with normal brain tissue and that this event tightly correlated with p53 mutations. Mechanistic...

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Identifiers

PMID: 28775165
DOI: 10.1158/0008-5472.CAN-17-1139

Genes

ZDHHC5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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