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Article

RAB27B controls palmitoylation-dependent NRAS trafficking and signaling in myeloid leukemia

14 Jun 2023

Abstract excerpt

RAS mutations are among the most prevalent oncogenic drivers in cancers. RAS proteins propagate signals only when associated with cellular membranes as a consequence of lipid modifications that impact their trafficking. Here, we discovered that RAB27B, a RAB family small GTPase, controlled NRAS palmitoylation and trafficking to the plasma membrane, a localization required for activation. Our proteomic studies...

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PMID: 37317963
DOI: 10.1172/jci165510

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