Article
ASSOCIATION BETWEEN HIGH MOBILITY GROUP BOX 1 PROTEIN GENE (rs41369348) POLYMORPHISM AND IMMUNOGLOBULIN A VASCULITIS IN CHILDREN.
Acta clinica Croatica - 1 Apr 2023
Batnožić Varga Mateja, Šestan Mario, Wagner Jasenka, Crkvenac Gornik Kristina, Kifer Nastasia, Frković Marijan, Stefinovec Laura, Vučemilović Jurić Valentina, Grgurić Danica, Pušeljić Silvija, Jelušić Marija
Abstract excerpt
Immunoglobulin A vasculitis (IgAV) or Henoch-Schönlein purpura is the most prevalent systemic small vessel vasculitis in childhood. High mobility group box 1 protein (HMBG1) is a pleiotropic cytokine that functions as a pro-inflammatory signal, important for the activation of antigen-presenting cells and propagation of inflammation. HMGB1 is implicated in the pathophysiology of a variety of inflammatory diseases....
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