Article
Association of monocyte chemoattractant protein 1 (MCP-1) gene polymorphism with lupus nephritis in Egyptian patients.
Human immunology - 1 Oct 2015
Mohammad Lamiaa A, Atef Dina M, Abul-Saoud Amany Mustafa
Abstract excerpt
BACKGROUND AND STUDY AIM: Monocyte chemoattractant protein-1 (MCP-1) is a member of CC chemokine that plays an important role in the recruitment of monocytes/macrophages into renal tubulointerstitium. A biallelic A/G polymorphism at position ∼2518 in the MCP-1 gene was found to regulate MCP-1 expression. MCP-1 and its A/G gene polymorphism have been implicated in the pathogenesis of some renal diseases. The aim...
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