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Article

Genome-wide association study of 7661 Chinese Han individuals and fine-mapping major histocompatibility complex identifies HLA-DRB1 as associated with IgA vasculitis.

Journal of clinical laboratory analysis - 1 Jun 2022

Xia Liang, Chen Mengyun, Zhang Hanshuo, Zheng Xiaodong, Bao Jing, Gao Jinping, Zhu Caihong, Sun Liangdan, Xia Hailong, Zhang Xuejun

Abstract excerpt

BACKGROUND: Immunoglobulin-A vasculitis (IgAV) is an immune-related systemic vasculitis with an unclear etiology. Genetic predisposition is now considered to be closely associated with the development of the disease, and it is essential to reveal the relationship between them. To explore the role of heredity in the disease, we performed a genome-wide association study (GWAS) of 496 IgAV cases and 7165 controls...

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Identifiers

PMID: 35470498
DOI: 10.1002/jcla.24457
PMCID: PMC9169162

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