Article
HLA-DPB1 variant rs3117242 is associated with anti-neutrophil cytoplasmic antibody-associated vasculitides in a Han Chinese population.
International journal of rheumatic diseases - 1 Aug 2017
Wu Ziyan, Wu Qingjun, Xu Juanjuan, Chen Si, Sun Fei, Li Ping, Bai Yina, Zheng Wenjie, Chen Hua, Zhang Fengchun, Li Yongzhe
Abstract excerpt
AIM: The vasculitis diseases granulomatosis with polyangiitis (GPA) and microscopic polyangitis (MPA) are the two major forms of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV). A recent genome-wide association study has shown that the genes HLA-DPB1 and HLA-DQ conferred susceptibility to GPA and MPA, respectively. We investigated the linkage between putative AAV-related genes (HLA-DPB1,...
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