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Article

High mobility group box 1 protein polymorphism affects susceptibility to recurrent pregnancy loss by up-regulating gene expression in chorionic villi.

Journal of assisted reproduction and genetics - 1 Jul 2015

Jin Hua, Wu Jie, Yang Qiuhong, Cai Yan, He Wenxiu, Liu Cuiying

Abstract excerpt

PURPOSE: Inflammation in chorionic villi is involved in the development of recurrent pregnancy loss (RPL). High mobility group box 1 protein (HMGB1) plays critical roles in inflammation and expression of the protein can be found in chorionic villi. The purpose of the study was to investigate the association between HMGB1 genetic polymorphisms and susceptibility to RPL and to examine the mechanism underlying this...

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Source

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Identifiers

PMID: 25956264
DOI: 10.1007/s10815-015-0493-3
PMCID: PMC4531873

Genes

HMGB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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