Article
Prognostic significance of high-mobility group box protein 1 genetic polymorphisms in rheumatoid arthritis disease outcome.
International journal of medical sciences - 1 Jan 2017
Wang Li-Hong, Wu Min-Huan, Chen Po-Chun, Su Chen-Ming, Xu Guohong, Huang Chien-Chung, Tsai Chun-Hao, Huang Yuan-Li, Tang Chih-Hsin
Abstract excerpt
Rheumatoid arthritis (RA) is a systemic inflammatory disease that causes chronic inflammation of the joints. Analysis of genetic variants offers promise for guiding treatment and improving outcomes in RA. High-mobility group box protein 1 (HMGB1) is a ubiquitous nuclear protein found in all mammal eukaryotic cells that participates in several biological functions including immune response, cell survival and...
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