Article
The Association of HMGB1 and RAGE Gene Polymorphisms with IgA Vasculitis.
Biochemical genetics - 1 Jun 2024
Batnozic Varga Mateja, Held Martina, Wagner Jasenka, Arvaj Nena, Sestan Mario, Sapina Matej, Kifer Nastasia, Grguric Danica, Crkvenac Gornik Kristina, Gagro Alenka, Frkovic Marijan, Jelusic Marija
Abstract excerpt
High-mobility group box 1 (HMGB1) is a pleiotropic cytokine that propagates inflammation by its extracellular action of interacting with the receptor for advanced glycation end products (RAGE). Both HMGB1 and RAGE play multiple roles in the pathogenesis of a variety of inflammatory and autoimmune diseases. We investigated the association of five single-nucleotide polymorphisms (SNPs) of the HMGB1 gene (rs1412125,...
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