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Article

Mulberrin extends lifespan in Caenorhabditis elegans through detoxification function.

Journal of applied toxicology : JAT - 1 Jun 2024

Gao Xiaoyan, Yu Jing, Zhang Lijun, Shi Hang, Yan Yingxuan, Han Yongli, Fang Minglv, Liu Ying, Wu Chengyuan, Fan Shengjie, Huang Cheng

Abstract excerpt

Mulberrin, a naturally occurring flavone found in mulberry and Romulus Mori, exhibits diverse biological functions. Here, we showed that mulberrin extended both the lifespan and healthspan in C. elegans. Moreover, mulberrin increased the worms' resistance to toxicants and activated the expression of detoxification genes. The longevity-promoting effect of mulberrin was attenuated in nuclear hormone receptor (NHR)...

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PMID: 38291015
DOI: 10.1002/jat.4578

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