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Pioglitazone Hydrochloride Extends the Lifespan of Caenorhabditis elegans by Activating DAF‐16/FOXO‐ and SKN‐1/NRF2‐Related Signaling Pathways

1 Jan 2022

Abstract excerpt

Pioglitazone hydrochloride (PGZ), a nuclear receptor peroxisome proliferator‐activated receptor gamma (PPAR‐γ) agonist, is a universally adopted oral agent for the treatment of type 2 diabetes (T2D). Previous studies reported that PGZ could ameliorate the symptoms of aging‐related diseases and Alzheimer’s disease. However, whether PGZ participates in aging regulation and the underlying mechanism remain...

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PMID: 35677109
DOI: 10.1155/2022/8496063

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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