Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The double shared epitope: Its impact on clinical features and ultrasound findings in rheumatoid arthritis.

International journal of rheumatic diseases - 1 Jan 2024

Michitsuji Tohru, Fukui Shoichi, Nishino Ayako, Endo Yushiro, Furukawa Kaori, Shimizu Toshimasa, Umeda Masataka, Sumiyoshi Remi, Koga Tomohiro, Iwamoto Naoki, Origuchi Tomoki, Kawakami Atsushi, Kawashiri Shin-Ya

Abstract excerpt

OBJECTIVES: The link between the HLA-DRB1 locus and the risk of rheumatoid arthritis (RA) shown in genome-wide association studies strengthens the shared epitope (SE) hypothesis. We aimed to assess the impact of the double dose of the SE (double SE) on RA and explore its clinical associations, including the response to abatacept. METHODS: We evaluated RA patients treated with csDMARDs or abatacept for HLA-DRB1...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Abatacept
Share to Alleles

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Arthritis, Rheumatoid

Share to Epitopes

Share to Genome-Wide Association Study

Share to HLA-DRB1 Chains

Source

Identifiers

PMID: 38287542
DOI: 10.1111/1756-185X.15030

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The double shared epitope: Its impact on clinical features and ultrasound findings in rheumatoid arthritis.PMID 38287542Read ↗

Brief Report: Main Contribution of DRB1*04:05 Among the Shared Epitope Alleles and Involvement of DRB1 Amino Acid Position 57 in Association With Joint Destruction in Anti-Citrullinated Protein Antibody-Positive Rheumatoid Arthritis.Semantic proximity Read ↗

HLA-DR risk variants in rheumatoid arthritis: what we know and still do not know.Semantic proximity Read ↗

Carriers of HLA-DRB1*04:05 have a better clinical response to abatacept in rheumatoid arthritisSemantic proximity Read ↗

Human Leukocyte Antigen Shared Epitope and Inflammation, Cardiovascular Disease, Cancer, and Mortality Among Postmenopausal Women in the Women's Health Initiative Rheumatoid Arthritis Study.Semantic proximity Read ↗

HLA class II and rheumatoid arthritis: the bumpy road of revelation.Semantic proximity Read ↗

Association between radiographic severity of rheumatoid arthritis and shared epitope alleles: differing mechanisms of susceptibility and protection.Semantic proximity Read ↗

HLA-DRB1 shared epitope allele polymorphisms and rheumatoid arthritis: a systemic review and meta-analysis.Semantic proximity Read ↗

An HLA-DRB1-coded signal transduction ligand facilitates inflammatory arthritis: a new mechanism of autoimmunity.Semantic proximity Read ↗

Associations between six classical HLA loci and rheumatoid arthritis: a comprehensive analysis.Semantic proximity Read ↗

Refining the complex rheumatoid arthritis phenotype based on specificity of the HLA-DRB1 shared epitope for antibodies to citrullinated proteins.Semantic proximity Read ↗

The HLA-DRB1 shared epitope alleles are primarily a risk factor for anti-cyclic citrullinated peptide antibodies and are not an independent risk factor for development of rheumatoid arthritis.Semantic proximity Read ↗

Particular HLA-DRB1 shared epitope genotypes are strongly associated with rheumatoid vasculitis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.