Article
Association between radiographic severity of rheumatoid arthritis and shared epitope alleles: differing mechanisms of susceptibility and protection.
Annals of the rheumatic diseases - 1 Jul 2008
Mewar D, Marinou I, Coote A L, Moore D J, Akil M, Smillie D, Dickson M C, Binks M H, Montgomery D S, Wilson A G
Abstract excerpt
OBJECTIVE: To investigate the association of a recently described classification of Human leukocyte antigen (HLA)-DRB1 shared epitope alleles with rheumatoid factors (RF) and anti-cyclic citrullinated peptide (CCP) production and radiological severity in rheumatoid arthritis (RA). METHODS: Patients with RA (n = 962) were studied. Genotyping of DRB1 alleles and assays for RF and anti-CCP were performed....
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