Article
Genomic characterization and immunotherapy for microsatellite instability-high in cholangiocarcinoma.
BMC medicine - 29 Jan 2024
Yang Xu, Lian Baofeng, Zhang Nan, Long Junyu, Li Yiran, Xue Jingnan, Chen Xiangqi, Wang Yunchao, Wang Yanyu, Xun Ziyu, Piao Mingjian, Zhu Chenpei, Wang Shanshan, Sun Huishan, Song Zhijian, Lu Leilei, Dong Xiaowei, Wang Aodi, Liu Wenjin, Pan Jie, Hou Xiaorong, Guan Mei, Huo Li, Shi Jie, Zhang Haohai, Zhou Jinxue, Lu Zhenhui, Mao Yilei, Sang Xinting, Wu Liqun, Yang Xiaobo, Wang Kai, Zhao Haitao
Abstract excerpt
BACKGROUND: Microsatellite instability-high (MSI-H) is a unique genomic status in many cancers. However, its role in the genomic features and immunotherapy in cholangiocarcinoma (CCA) is unclear. This study aimed to systematically investigate the genomic characterization and immunotherapy efficacy of MSI-H patients with CCA. METHODS: We enrolled 887 patients with CCA in this study. Tumor samples were collected...
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