Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Perivascular space burden interacts with APOE-ε4 status on cognition in older adults.

Neurobiology of aging - 1 Apr 2024

Gogniat Marissa A, Khan Omair A, Bown Corey W, Liu Dandan, Pechman Kimberly R, Taylor Davis L, Gifford Katherine A, Landman Bennett A, Hohman Timothy J, Jefferson Angela L

Abstract excerpt

Enlarged perivascular spaces (ePVS) may adversely affect cognition. Little is known about how basal ganglia ePVS interact with apolipoprotein (APOE)-ε4 status. Vanderbilt Memory and Aging Project participants (n = 326, 73 ± 7, 59% male) underwent 3 T brain MRI at baseline to assess ePVS and longitudinal neuropsychological assessments. The interaction between ePVS volume and APOE-ε4 carrier status was related to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apolipoprotein E4
Share to Cognition

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Aged, 80 and over

Share to Cross-Sectional Studies

Share to Genotype

Share to Neuropsychological Tests

Source

Open in PubMed Open full text

Identifiers

PMID: 38280312
DOI: 10.1016/j.neurobiolaging.2024.01.002
PMCID: PMC11384903

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Perivascular space burden interacts with APOE-ε4 status on cognition in older adults.PMID 38280312Read ↗

Alterations in MRI-visible perivascular spaces precede dementia diagnosis by 18 years in autosomal dominant Alzheimer's disease.Semantic proximity Read ↗

Association of MRI-measured cerebral ventricular volume with APOE ε4 genotype, cerebrospinal fluid biomarkers (Aβ42 and Tau) and neuropsychological measures in Alzheimer’s disease: A Systematic ReviewSemantic proximity Read ↗

Enlarged perivascular spaces are associated with decreased brain tau depositionSemantic proximity Read ↗

APOE-ε4 risk variant for Alzheimer's disease modifies the association between cognitive performance and cerebral morphology in healthy middle-aged individualsSemantic proximity Read ↗

Interaction of APOE, cerebral blood flow, and cortical thickness in the entorhinal cortex predicts memory decline.Semantic proximity Read ↗

Multidomain determinants of perivascular spaces indicate early cerebrovascular vulnerability in individuals at risk of Alzheimer’s diseaseSemantic proximity Read ↗

Associations between APOE genotype and cerebral small-vessel disease: a longitudinal study.Semantic proximity Read ↗

Ventricular expansion, white matter hyperintensities, and global cognition in Alzheimer’s disease and normal agingSemantic proximity Read ↗

<i>APOE4</i> poses opposite effects of plasma LDL on white matter integrity in older adultsSemantic proximity Read ↗

Effects of APOE-ε4 allele load on brain morphology in a cohort of middle-aged healthy individuals with enriched genetic risk for Alzheimer's disease.Semantic proximity Read ↗

Impact of APOE-ε alleles on brain structure and cognitive function in healthy older adults: A VBM and DTI replication study.Semantic proximity Read ↗

Apolipoprotein ε4 is associated with lower brain volume in cognitively normal Chinese but not white older adults.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.