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Article

Association between Plasma Brain-derived Neurotrophic Factor Level and Alzheimer's Disease: A Mendelian Randomization Study.

Current neurovascular research - 1 Jan 2024

You Jiaxing, Wang Yinan, Chang Xinyue, Liu Yi, He Yu, Zhou Xiya, Zou Jinyan, Xiao Meng, Shi Mengyao, Guo Daoxia, Shen Ouxi, Zhu Zhengbao

Abstract excerpt

BACKGROUND: High brain-derived neurotrophic factor (BDNF) concentrations have been found to be associated with a decreased risk of Alzheimer's disease (AD) in observational studies, but the causality for this association remains unclear. Therefore, we aimed to examine the association between genetically determined plasma BDNF levels and AD using a two-sample Mendelian randomization (MR) method. METHODS: Twenty...

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PMID: 38279765
DOI: 10.2174/0115672026281995231227070637

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