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Article

PRKN-regulated mitophagy and cellular senescence during COPD pathogenesis

6 Oct 2018

Abstract excerpt

Cigarette smoke (CS)-induced accumulation of mitochondrial damage has been widely implicated in chronic obstructive pulmonary disease (COPD) pathogenesis. Mitophagy plays a crucial role in eliminating damaged mitochondria, and is governed by the PINK1 (PTEN induced putative protein kinase 1)-PRKN (parkin RBR E3 ubiquitin protein ligase) pathway. Although both increased PINK1 and reduced PRKN have been implicated...

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PMID: 30290714
DOI: 10.1080/15548627.2018.1532259

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