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Article

Murine Progeria Model Exhibits Delayed Fracture Healing With Senescent Phenotype and Dysregulated Immune Response.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society - 1 Apr 2026

Duke Victoria R, Philippon Marc J, Lind Dane R G, Kasler Herbert, Yamaura Kohei, Huard Matt, Czachor Molly, Hollenbeck Justin, Brown Justin, Garcia Alex, Matityahu Jacob D, Fukase Naomasa, Marcucio Ralph S, Nelson Anna-Laura, Hambright William S, Snapper Dustin M, Huard Johnny, Bahney Chelsea S

Abstract excerpt

An estimated 189 million bone fractures occurred in 2019 making it one of the most globally prevalent injuries. Delayed union or nonunion occurs in up to 15% of normal fractures with higher rates in aged individuals. Preclinical testing supports the translation of novel strategies to promote improved fracture repair, but there is a paucity of small animal models that recapitulate delayed fracture healing. Here,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41934203
DOI: 10.1002/jor.70193
PMCID: PMC13049502

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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