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Article

Atypical chemokine receptors

26 Jan 2011

Abstract excerpt

Atypical chemokine receptors (ACRs) are cell surface receptors with seven transmembrane domains structurally homologous to chemokine G-protein coupled receptors (GPCRs). However, upon ligation by cognate chemokines, ACRs fail to induce classical signaling and downstream cellular responses characteristic for GPCRs. Despite this, by affecting chemokine availability and function, ACRs impact on a multitude of...

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PMID: 21272574
DOI: 10.1016/j.yexcr.2011.01.012

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