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Article

Crosstalk between CXCL12/CXCR4/ACKR3 and the STAT3 Pathway

13 Jun 2024

Abstract excerpt

The reciprocal modulation between the CXCL12/CXCR4/ACKR3 axis and the STAT3 signaling pathway plays a crucial role in the progression of various diseases and neoplasms. Activation of the CXCL12/CXCR4/ACKR3 axis triggers the STAT3 pathway through multiple mechanisms, while the STAT3 pathway also regulates the expression of CXCL12. This review offers a thorough and systematic analysis of the reciprocal regulatory...

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PMID: 38920657
DOI: 10.3390/cells13121027

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