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Article

The Distinct Roles of CXCR3 Variants and Their Ligands in the Tumor Microenvironment

18 Jun 2019

Abstract excerpt

First thought to orchestrate exclusively leukocyte trafficking, chemokines are now acknowledged for their multiple roles in the regulation of cell proliferation, differentiation, and survival. Dysregulation of their normal functions contributes to various pathologies, including inflammatory diseases and cancer. The two chemokine receptor 3 variants CXCR3-A and CXCR3-B, together with their cognate chemokines...

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PMID: 31216755
DOI: 10.3390/cells8060613

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