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Chromatin Remodelers Are Regulators of the Tumor Immune Microenvironment

24 Jan 2024

Abstract excerpt

Immune checkpoint inhibitors show remarkable responses in a wide range of cancers, yet patients develop adaptive resistance. This necessitates the identification of alternate therapies that synergize with immunotherapies. Epigenetic modifiers are potent mediators of tumor-intrinsic mechanisms and have been shown to regulate immune response genes, making them prime targets for therapeutic combinations with immune...

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PMID: 38266066
DOI: 10.1158/0008-5472.can-23-2244

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