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Article

Wedding of Molecular Alterations and Immune Checkpoint Blockade: Genomics as a Matchmaker

2 Apr 2021

Abstract excerpt

The development of checkpoint blockade immunotherapy has transformed the medical oncology armamentarium. But despite its favorable impact on clinical outcomes, immunotherapy benefits only a subset of patients, and a substantial proportion of these individuals eventually manifest resistance. Serious immune-related adverse events and hyperprogression have also been reported. It is therefore essential to understand...

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PMID: 33823006
DOI: 10.1093/jnci/djab067

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