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AgrA directly binds to the promoter of vraSR and downregulates its expression in Staphylococcus aureus

23 Jan 2024

Abstract excerpt

ABSTRACT Staphylococcus aureus is an important human pathogen and vancomycin is widely used for the treatment of S. aureus infections. The global regulator agr is known as a well-described virulence regulator. Previous studies have found that agr -dysfunction strains are more likely to develop into vancomycin-resistant strains, but the mechanism for this phenomenon remains unknown. VraSR is a two-component...

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PMID: 38259090
DOI: 10.1128/aac.00893-23

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