Therapeutic Targeting of the Staphylococcus aureus Accessory Gene Regulator (agr) System

Abstract excerpt

S. aureus can cause numerous different diseases, which has been attributed to its large repertoire of virulence factors, many of which are under the control of the accessory gene regulator (agr) quorum sensing system. Under conditions of high cell density, agr increases the production of many virulence factors, decreases expression of several colonization factors, and is intimately associated with the...