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Article

Decreased Vancomycin Susceptibility in Staphylococcus aureus Caused by IS <i>256</i> Tempering of WalKR Expression

30 Apr 2013

Abstract excerpt

Vancomycin-intermediate Staphylococcus aureus (VISA) strains often arise by mutations in the essential two-component regulator walKR; however their impact on walKR function has not been definitively established. Here, we investigated 10 MRSA strains recovered serially after exposure of vancomycin-susceptible S. aureus (VSSA) JKD6009 to simulated human vancomycin dosing regimens (500 mg to 4,000 mg every 12 h)...

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Identifiers

PMID: 23629723
DOI: 10.1128/aac.00279-13

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