Article
Genome Plasticity of agr-Defective Staphylococcus aureus during Clinical Infection.
Infection and immunity - 1 Oct 2018
Altman Deena R, Sullivan Mitchell J, Chacko Kieran I, Balasubramanian Divya, Pak Theodore R, Sause William E, Kumar Krishan, Sebra Robert, Deikus Gintaras, Attie Oliver, Rose Hannah, Lewis Martha, Fulmer Yi, Bashir Ali, Kasarskis Andrew, Schadt Eric E, Richardson Anthony R, Torres Victor J, Shopsin Bo, van Bakel Harm
Abstract excerpt
Therapy for bacteremia caused by Staphylococcus aureus is often ineffective, even when treatment conditions are optimal according to experimental protocols. Adapted subclones, such as those bearing mutations that attenuate agr-mediated virulence activation, are associated with persistent infection and patient mortality. To identify additional alterations in agr-defective mutants, we sequenced and assembled the...
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