Article
Mutated response regulator graR is responsible for phenotypic conversion of Staphylococcus aureus from heterogeneous vancomycin-intermediate resistance to vancomycin-intermediate resistance.
Antimicrobial agents and chemotherapy - 1 Jan 2008
Neoh Hui-min, Cui Longzhu, Yuzawa Harumi, Takeuchi Fumihiko, Matsuo Miki, Hiramatsu Keiichi
Abstract excerpt
Multistep genetic alteration is required for methicillin-resistant Staphylococcus aureus (MRSA) to achieve the level of vancomycin resistance of vancomycin-intermediate S. aureus (VISA). In the progression of vancomycin resistance, strains with heterogeneous vancomycin resistance, designated hetero-VISA, are observed. In studying the whole-genome sequencing of the representative hetero-VISA strain Mu3 and...
Topics
- Anti-Bacterial Agents
- Bacterial Proteins
- Gene Expression Regulation, Bacterial
- Genome, Bacterial
- Humans
- Microbial Sensitivity Tests
- Mutation
- Oligonucleotide Array Sequence Analysis
- Phenotype
- Sequence Analysis, DNA
- Signal Transduction
- Staphylococcus aureus